Publications Relevant to MVI Immunotherapies

Primary scientific articles, review articles, editorials, and invited book chapters from the McNeel Laboratory

Primary scientific publications

  1. Kyriakopoulos CE, Eickhoff JC, Ferrari AC, Schweizer MT, Wargowski E, Olson BM, and McNeel DG.  (2020)  “Multicenter phase 1 trial of a DNA vaccine encoding the androgen receptor ligand binding domain (pTVG-AR, MVI-118) in patients with metastatic prostate cancer.”  Clin Cancer Res 26:5162-71.  (PMID: 32513836, PMCID: PMC7541575)
  2. Zahm CD, Johnson LE, and McNeel DG.  (2019) “Increased indoleamine 2,3-dioxygenase activity and expression in prostate cancer following targeted immunotherapy.”  Cancer Immunol Immunoth 68:1661-1669.  (PMID: 31606777, PMCID: PMC7111534)
  3. McNeel DG, Eickhoff JC, Johnson LE, Roth AR, Perk TG, Fong L, Antonarakis ES, Wargowski E, Jeraj R, and Liu G.  (2019)  “Randomized phase 2 trial of a DNA vaccine encoding prostatic acid phosphatase (pTVG-HP, MVI-816) in patients with progressive non-metastatic, castration-sensitive prostate cancer.”  J Clin Oncol  37:3507-3517.  (PMID: 31644357, PMCID: 7194451)
  4. Scarpelli M, Zahm CD, Perlman S, McNeel DG, Jeraj R, and Liu G.  (2019)  “FLT PET/CT imaging of metastatic prostate cancer patients treated with pTVG-HP DNA vaccine and pembrolizumab.”  Journal ImmunoTherapy of Cancer 7:23.  (PMID: 30700328, PMCID: PMC6354338)
  5. McNeel DG, Eickhoff JC, Wargowski E, Zahm CD, Staab MJ, Straus J, and Liu G.  (2018)  “Concurrent, but not sequential, PD-1 blockade with a DNA vaccine elicits anti-tumor responses in patients with metastatic, castration-resistant prostate cancer.”  Oncotarget 9:25586-25596.  (PMID: 29876010, PMCID: PMC5986652)
  6. Johnson LE, Brockstedt D, Leong M, Lauer P, Theisen E, Sauer J-D, and McNeel DG.  (2018)  “Heterologous vaccination targeting prostatic acid phosphatase (PAP) using DNA and Listeria vaccines elicits superior anti-tumor immunity dependent on CD4+ T cells elicited by DNA priming.”  Oncoimmunology 7:e1456603.  (PMID: 30221049, PMCID: PMC6136874)
  7. Wargowski E, Johnson LE, Eickhoff JC, Delmastro L, Staab MJ, Liu G, and McNeel DG.  (2018)  “Prime-boost vaccination targeting prostatic acid phosphatase (PAP) in patients with metastatic castration-resistant prostate cancer (mCRPC) using sipuleucel-T and a DNA vaccine.”  Journal ImmunoTherapy of Cancer 6:21.  (PMID: 29534736, PMCID: PMC5850960)  
  8. Olson BM, Gamat M, Seliski J, Sawicki T, Jeffery J, Ellis L, Drake CG, Weichert J, and McNeel DG.  (2017)  “Prostate cancer cells express more androgen receptor (AR) following androgen deprivation, improving recognition by AR-specific T cells.”  Canc Imm Res  5:1074-1082.  (PMID:  29051161, PMCID: PMC5873299)
  9. Johnson LE, Olson BM, and McNeel DG.  (2017)  “Pretreatment antigen-specific immunity and regulation – association with subsequent immune response to anti-tumor DNA vaccination.”  J ImmunoTherapy Cancer  5:56-66.  (PMID: 28716080, PMCID: PMC5514519)
  10. Zahm CD, Colluru VT, and McNeel DG.  (2017)  “Vaccination with high-affinity epitopes impairs antitumor efficacy by increasing PD-1 expression on CD8+ T cells”  Canc Imm Res 5:630-641.  (PMID: 28634215, PMCID: PMC5821110)
  11. Olson BM, Bradley E, Sawicki T, Zhong W, Ranheim EA, Bloom JE, Colluru V, Johnson LE, Rekoske BT, Eickhoff JC, and McNeel DG.  (2017)  “Safety and immunological efficacy of a DNA vaccine encoding the androgen receptor ligand-binding domain (AR-LBD).”  Prostate 77:812-821.  (PMID 28181678, PMCID: PMC5382038)
  12. McNeel DG, Bander NH, Beer TM, Drake CG, Fong L, Harrelson S, Kantoff PW, Madan RA, Oh WK, Peace DJ, Petrylak DP, Porterfield H, Sartor O, Shore ND, Slovin SF, Stein MN, Vieweg J, and Gulley JL. (2016) “The Society for Immunotherapy of Cancer Consensus Statement on Tumor Immunotherapy for the Treatment of Prostate Carcinoma.”  J ImmunoTherapy Cancer 4:92-103.  (PMID: 28031820, PMCID: PMC5170901)
  13. Colluru VT and McNeel DG.  (2016)  “B lymphocytes as direct antigen-presenting cells for anti-tumor DNA vaccines.”  Oncotarget 7:67901-67918.  (PMID: 27661128, PMCID: PMC5356528)
  14. Colluru VT, Zahm CD, and McNeel DG.  (2016)  “Mini-intronic plasmid vaccination elicits tolerant LAG3+ CD8 T cells and inferior anti-tumor responses.”  Oncoimmunology 5:e1223002.  (PMID: 27853647, PMCID: PMC5087309)
  15. Rekoske BT, Olson BM, and McNeel DG.  (2016)  “Anti-tumor vaccination of prostate cancer patients elicits PD-1/PD-L1 regulated antigen-specific immune responses.”  Oncoimmunology 5:e1165377.  (PMID: 27471641, PMCID: PMC4938302)
  16. Rekoske BT, Smith HA, Olson BM, Maricque BB, and McNeel DG.  (2015)  “PD-1 or PD-L1 blockade restores anti-tumor efficacy following SSX2 epitope-modified DNA vaccine immunization.”  Canc Imm Res 3:946-955.  (PMID: 26041735, PMCID: PMC4527948)
  17. McNeel DG, Becker JT, Eickhoff JC, Johnson LE, Bradley E, Pohlkamp I, Staab MJ, Liu G, Wilding G, and Olson BM.  (2014)  “Real-time immune monitoring to guide plasmid DNA vaccination schedule targeting prostatic acid phosphatase (PAP) in patients with castration-resistant prostate cancer.”  Clin Can Res 20:3692-3704.  (PMID: 24850844, PMCID: PMC4102643)
  18. Smith HA, Rekoske BT, McNeel DG.  (2014)  “DNA vaccines encoding altered peptide ligands for SSX2 enhance epitope-specific CD8+ T-cell immune responses.”  Vaccine 32:1707-1715.  (PMID:  24492013, PMCID:  PMC4153342)
  19. Becker JT and McNeel DG.  (2013)  “Presence of antigen-specific somatic allelic mutations and splice variants do not predict for immunological response to genetic vaccination.”  J ImmunoTher Cancer  1:2.  (PMID: 24764533, PMCID: PMC3986973)
  20. Johnson LE, Becker JT, Dubovsky JA, Olson BM, and McNeel DG.  (2013)  “Prostate carcinoma in transgenic Lewis rats – A tumor model for evaluation of immunological treatments.”  Chin. Clin. Oncol.  2:4-12 (  (PMID: 24324949, PMCID: PMC3855422).
  21. Olson BM, Jankowska-Gan E, Becker JT, Vignali DAA, Burlingham WJ, and McNeel DG.  (2012)  “Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade.”  J. Immunol.  189:5590-5601.  (PMID: 23152566, PMCID: PMC3735346)
  22. Johnson LE, Frye TP, and McNeel DG.  (2012)  “Immunization with a prostate cancer xenoantigen elicits a xenoantigen epitope-specific T-cell response.”  OncoImmunology 1:1546-1556.  (PMID: 23264901, PMCID: PMC3525610)
  23. Olson BM, Johnson LE, and McNeel DG.  (2013)  “The androgen receptor – a biologically-relevant vaccine target for the treatment of prostate cancer.”  Cancer Immunol. Immunoth.  62:585-596.  (PMID: 23108626, PMD: PMC3577997)
  24. Johnson LE and McNeel DG.  (2012)  “Identification of prostatic acid phosphatase (PAP) specific HLA-DR1-restricted T-cell epitopes.”  Prostate  72:730-740.  (PMID: 22529020)
  25. Olson BM and McNeel DG.  (2011)  “CD8+ T cells specific for the androgen receptor are common in patients with prostate cancer and are able to lyse prostate tumor cells.”  Cancer Immunol. Immunoth.  60:781-792.  (PMID: 21350948, PMCID: PMC3319721).
  26. Smith HA, Maricque BB, Eberhardt J, Petersen B, Gulley JL, Schlom J, and McNeel DG.  (2011)  “IgG responses to tissue-associated antigens as biomarkers of immunological treatment efficacy.”  J. Biomed. Biotech.  2011:454861.  (PMID: 21197272, PMCID: PMC3010827)
  27. Becker JT, Olson BM, Johnson LE, Davies JG, Dunphy EJ, and McNeel DG.  (2010)  “DNA vaccine encoding prostatic acid phosphatase (PAP) elicits long-term T-cell responses in patients with recurrent prostate cancer.”  J Immunotherapy 33:639-647.  (PMID 20153396, PMCID: PMC3045767).
  28. Olson BM, Frye TP, Johnson LD, Fong L, Knutson KL, Disis ML, and McNeel DG.  (2010) “HLA-A2-restricted T-cell epitopes specific for prostatic acid phosphatase.”  Cancer Immunol. Immunother.  59:943-953.  (PMID 20140431, PMCID: PMC3038205)
  29. McNeel DG, Dunphy EJ, Davies JG, Frye TP, Johnson LE, Staab MJ, Horvath DL, Straus J, Alberti D, Marnocha R, Liu G, Eickhoff JC, and Wilding G.  (2009)  “Safety and immunological efficacy of a DNA vaccine encoding prostatic acid phosphatase (PAP) in patients with stage D0 prostate cancer.”  J. Clin. Oncol. 27:4047-4054.  (PMID: 19636017, PMCID:  PMC2734418)
  30. Olson BM and McNeel DG.  (2007)  “Antibody and T-cell responses specific for the androgen receptor in patients with prostate cancer.”  Prostate 67:1729-1739.  (PMID:  17879963)
  31. Johnson LE, Frye TP, Chinnasamy D, Chinnasamy N, and McNeel DG.  (2007)  “Plasmid DNA vaccine encoding prostatic acid phosphatase (PAP) effective in eliciting autologous antigen-specific CD8 T cells.”  Cancer Immunol Immunother  56:885-895.  (PMID:  17102977)
  32. Johnson LE, Frye TP, Arnot AR, Marquette C, Couture LA, Gendron-Fitzpatrick A, and McNeel DG.  (2006)  “Safety and immunological efficacy of a prostate cancer plasmid DNA vaccine encoding prostatic acid phosphatase (PAP).”  Vaccine 24:293-303.  (PMID:  16115700)
  33. Zlotocha S, Staab MJ, Horvath D, Straus J, Dobratz J, Oliver K, Wasielewski S, Alberti D, Liu G, Wilding G, Eickhoff J, and McNeel DG.  (2005)  “A phase I study of a DNA vaccine targeting prostatic acid phosphatase (PAP) in patients with stage D0 prostate cancer.”  Clin. Genitourinary Cancer  4:215-218.  (PMID:  16425992)
  34. Disis ML, Shiota FM, McNeel DG and Knutson KL.  (2003)  “Soluble cytokines can act as effective adjuvants in plasmid DNA vaccines targeting self-tumor antigens.”  Immunobiology  207:1-8.  (PMID:  12777059)
  35. McNeel DG, Nguyen LD and Disis ML.  (2001)  “Identification of T helper epitopes derived from prostatic acid phosphatase.”  Cancer Res. 61:5161-5167.  (PMID:  11431355)
  36. McNeel DG, Nguyen LD, Ellis WJ, Higano CS, Lange PH and Disis ML.  (2001)  “Naturally occurring prostate cancer antigen-specific T cell responses of a Th1 phenotype can be detected in patients with prostate cancer.”  Prostate 47:222-229.  (PMID:  11351352)
  37. McNeel DG, Nguyen LD, Storer BE, Vessella R, Lange PH and Disis ML.  (2000)  “Antibody immunity to prostate cancer-associated antigens can be detected in the serum of patients with

Peer-reviewed, review articles or editorials

  1. McNeel DG.  (2018)  “Therapeutic Cancer Vaccines:  How Much Closer Are We?”  BioDrugs 32:1-7.  (PMID 29285731, PMCID: PMC5815920)
  2. Gamat M and McNeel DG.  (2017)  “Androgen deprivation and immunotherapy for the treatment of prostate cancer.”  Endocrine-Related Cancer 24:T297-T310.  (PMID: 28814451, PMCID: PMC5669826)
  3. Zahm CD, Colluru VT, and McNeel DG.  (2017)  “DNA vaccines for prostate cancer.”  Pharmacol Ther 174:27-42.  (PMID: 28185916, PMCID:  PMC5429198)
  4. Rekoske BT and McNeel DG.  (2016)  “Immunotherapy for Prostate Cancer:  False Promises or True Hope?”  Cancer 122:3598-3607.  (PMID:  27649312, PMCID:  PMC5115970)
  5. Colluru VT, Johnson LE, Olson BM, and McNeel DG.  (2016)  “Preclinical and clinical development of DNA vaccines for prostate cancer.”  Urol. Oncol. 34:193-204.  (PMID: 24332642, PMCID: PMC4053490)
  6. Olson BM and McNeel DG.  (2013)  “Monitoring regulatory immune responses in tumor immunotherapy clinical trials.”  Front. Oncol. 3:1-11. (PMID: 23653893, PMCID: PMC3644716)
  7. McNeel DG, Becker JT, Johnson LE, and Olson BM.  (2012)  “DNA vaccines for prostate cancer.”  Curr. Cancer Ther. Rev. 8:245-253.  (PMID: 24587772, PMCID: PMC3935480)
  8. Alam S and McNeel DG.  (2010)  “DNA vaccines for the treatment of prostate cancer.”  Exp. Rev. Vaccines  9:731-745.  (PMID: 20624047)
  9. Kipp RT and McNeel DG.  (2007)  “Immunotherapy of prostate cancer.”  Clin. Adv. Hem. Onc.  5:465-479.  (PMID:  17679921)
  10. McNeel DG.  (2007)  “Prostate cancer immunotherapy.”  Curr. Opin. Urol. 17:175-181.  (PMID:  17414515)
  11. McNeel DG.  (2007)  “Cellular immunotherapies for prostate cancer.”  Biomed Pharmacother. 61:315-322.  (PMID:  17306498)
  12. Dunphy EJ, Johnson LE, Olson BM, Frye TP, and McNeel DG.  (2006)  “New approaches to identification of antigenic candidates for future prostate cancer immunotherapy.”  Update on Cancer Therapeutics 22:273-284.
  13. McNeel DG and Malkovsky M.  (2005)  “Immune-based therapies for prostate cancer.”  Immunol. Lett. 96:3-9.  (PMID:  15585302)
  14. McNeel DG, Disis ML.  (2000)  “Tumor vaccines for the management of prostate cancer.” Arch. Immunol. Ther. Exp. 48:85-93.  (PMID:  10807048)

Invited, peer-reviewed book chapters

  1. Bradley ES and McNeel DG.  “DNA Vaccines.”  Marshall JL ed. Encyclopedia of Cancer Therapeutic Targets.  New York:  Springer, 2016.
  2. Olson BM and McNeel DG.  “Engineering DNA vaccines for cancer therapy.”  Cai W ed.  Engineering in Translational Medicine, Chapter 17.  London:  Springer-Verlag, 2014.  
  3. Olson BM and McNeel DG.  “Methods for constructing and evaluating anti-tumor DNA vaccines.”  Walther W, Stein US eds.  Methods in Molecular Biology, Gene Therapy of Cancer, vol. 542.  Totowa: Humana Press, 2009 p. 211-243.  (PMID:  19565905)
  4. McNeel DG.  “Prostate cancer antigens and vaccines, preclinical developments.”  In:  Giaccone G, Schilsky R, Sondel P. eds.  Cancer Chemotherapy and Biological Response Modifiers, Annual 22.  Oxford:  Elsevier Limited, 2005 p. 247-261.  (PMID:  16110615)

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